Chlorhexidine gluconate (CHX) mouth rinse is a well-known and effective antimicrobial rinse option, used most often in dentistry for control of plaque associated with periodontal disease (including gingivitis) and adjunctive use between dental visits for the treatment of gingivitis. There are also less common indications, for example in the management of dental caries (an off-label use).
Before reviewing these, depending on the country you practice in, it is important to be aware that some or all of the following uses may be off-label/unlicensed uses for you and that while there is evidence for some uses there is less certain evidence for others.
The Pharmaceutical Journal states that CHX can be prescribed and recommended for the following:
A recent systematic review found moderate evidence that pre-procedural mouth rinsing with antiseptics, such as CHX, can reduce intraoral bacterial loads and therefore the level of bacteria aerosolized during dental procedures. This is an unlicensed/off-label use. The same review noted evidence for plaque reductions and for use in patients with gingivitis or dry sockets. However, it found 'less certain evidence' for other uses.
CHX mouth rinse is available in two concentrations, either as a 0.20% formulation or as a 0.12% formulation such as Colgate PerioGard (available in the United States). While one is a higher concentration than the other, the amount used is inversely related to the concentration. The formulations are equally effective in controlling plaque and for use in patients with gingivitis.
CHX is a versatile rinse, effective for several uses as part of professional and home care. It is important to understand which uses are off-label or unlicensed uses and which are indications where you practice.
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