Arginine and the new era of oral health
Evidence shows that adding Arginine to differenct oral care technologies can have positive effects –
from sensitivity relief1, to caries prevention2, to non-stop* biofilm control3-6 for healthy gums7.
See some of the more than 100 published studies across indications.
*with 2x daily brushing and 4 weeks continued use
Biofilm Control
for Healthy Gums
Arginine helps deliver zinc for non-stop• biofilm control.
Caries
Prevention
Arginine complements fluoride for enhanced cavity protection.
Sensitivity
Relief
Arginine works with Calcium Carbonate for superior† instant‡ and long lasting§ sensitivity relief.
*with 2x daily brushing and 4 weeks continued use
†vs a potassium nitrate toothpaste
‡For instant relief, apply as directed to the sensitive tooth with finger tip and gently massage for 1 minute.
§Lasting relief with 2x daily continued brushing.
The Science of Arginine
Naturally occuring in saliva, Arginine is an amino acid that's been studied for its unique properties that support oral health...including its ability to balance the oral microbiome.
Learn how Colgate scientists are harnessing the power of Arginine
combined with oral ingredients such as zinc, fluoride, or calcium carbonate.
Non-stop* biofilm control3-6
for healthy gums7
Restores healthy
plaque pH2
Block tubules to
relieve sensitivity8
Positive results with Arginine have led to expanding its use in oral health –
and Colgate scientists, along with academic partners, will continue to conduct research to see how it can create higher standards in oral care.
*with 2x daily brushing and 4 weeks continued use
References: 1. Ayad F, Ayad N, Vazquez J, et al. Use of a toothpaste containing 8% arginine and calcium carbonate for immediate and lasting relief of dentin hypersensitivity: A simple and effective in-office procedure. Am J Dent. 2018;31(3):135-140. 2. Cantore R, Petrou I, Lavender S, et al. In situ clinical effects of new dentifrices containing 1.5% arginine and fluoride on enamel de- and remineralization and plaque metabolism. J Clin Dent. 2013;24(Spec Iss A):A32-44. 3. Manus LM, Daep CA, Begum-Gafur R, et al. Enhanced in vitro zinc bioavailability through rational design of a dual zinc plus arginine dentrifice. J Clin Dent. 2018;29(Spec Iss A):A10-19. 4. Gloag E, Khosravi Y, Masters JG, et al. Zinc and arginine mechanically destabilizes dental biofilms. J Dent Res. 2021;100(Spec Iss A):0999. 5. Daep C, et al. August 2019. Data on file. 6. Prasad KV, Therathil SG, Agnihotri A, et al. The effects of two new dual zinc plus arginine dentifrices in reducing oral bacteria in multiple locations in the mouth: 12-hour whole mouth antibacterial protection for whole mouth health. J Clin Dent. 2018;29(Spec Iss A):A25-32. 7. Delgado E, Garcia-Godoy F, Montero-Aguilar M, et al. A clinical investigation of a dual zinc plus arginine dentifrice in reducing established dental plaque and gingivitis over a six-month period of product use. J Clin Dent. 2018;29(Spec Iss A):A33-40. 8. Hines D, Rinaudi-Marron L, Xu S, et al. Comparative study of dentin occlusion by commercially available toothpastes. Poster #3406. Presented at the International Association of Dental Research Conference; July 28, 2018; London, England.
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The science of arginine
Naturally occuring in saliva, Arginine is an amino acid that's been studied for its unique properties that support oral health...including its ability to balance the oral microbiome.
Learn how Colgate scientists are harnessing the power of Arginine
combined with oral ingredients such as zinc, fluoride, or calcium carbonate.
Non-stop* biofilm control3-6
for healthy gums7
Restores healthy
plaque pH2
Block tubules to
relieve sensitivity8
Positive results with Arginine have led to expanding its use in oral health –
and Colgate scientists, along with academic partners, will continue to conduct research to see how it can create higher standards in oral care.
*with 2x daily brushing and 4 weeks continued use
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Setting a new standard in oral care
Extensive research has established a new era of possibilities
